HONG KONG POLYTECHNIC UNIVERSITY
Description:
The Hong Kong Polytechnic University is the largest UGC-funded tertiary institution in terms of numbers of students (more than 16000). A wide range of courses which directly meets industrial, commercial and community needs is offered. The Hong Kong Polytechnic University (PolyU)’s Shenzhen-based Institute of Modern Chinese Medicine has been designated as a key laboratory specializing in traditional Chinese medicine products and related pharmacology, and will provide a platform for the research and development of pharmaceutical products. The institute is equipped with state-of-the-art facilities over an area of 2,000-square-meter, and is home to the Open Laboratory of Chirotechnology, SPF- (Specific Pathogen Free) Standard Animal Laboratory, GMP- (Good Manufacturing Practice) Standard Formulation Laboratory, DNA Chips Laboratory, and other laboratories for TCM pharmacology, TCM chemistry, toxicology and molecular pharmacology.
The Department of The Hong Kong Polytechnic University that participates to the project is the Department of Applied biology & Chemical Technology,and in particular the research group led by Prof. Albert Sun Chi Chan.
The task of Professor Chan’s group in CATAFLU.OR project are related to the development of organocatalytic reactions for the synthesis of neuraminidase inhibitor, through different reactions schemes from those examined by other groups. In addition, a key study will be developed in Chan’s group regarding the in silico approach in order to guide all the project toward an efficient synthesis of a new, effective and useful drug candidate.
Prof. Albert Sun Chi Chan leads a research group within the Department of Applied biology & Chemical Technology at the Hong Kong Polytechnic University. He is the Dean of the Faculty of Applied Science and Textile He started his career in USA, where held his Ph.D and move to work for Monsanto. He has an important publication records in the area of asymmetric catalysis, asymmetric hydrogenation. Among his interests he is active in practical Chinese medicine, collaborating with many universities in China. He has established a predominant and highly successful group in Hong Kong, Prof. Chan’s group has developed several chiral diphosphine ligands, such as P-Phos series and PQ-Phos series ligands for asymmetric hydrogenation, and excellent results have been obtained. Prof. Chan’s group has published over 300 papers in international peer-reviewed journals including J. Am. Chem. Soc., Angew. Chem. Int. Ed., Chem. Commun., and PNAS, and has reached international reputation in the area of asymmetric catalysis.
While Prof. Chan coordinates The Hong Kong Polytechnic University Team, Dr. Li is in charge of the whole project. In addition, two Ph.D. students and one post doctoral research fellow are involved during the completion of the project. Yue-Ming Li (The Hong Kong Polytechnic University). Dr. Li’s research interests are organic synthesis, medicinal chemistry, and computer-aided drug design. In addition to the work in asymmetric organic synthesis, he has been involved in the design and synthesis of novel telomerase inhibitors, and new compounds for cardiovascular diseases.